Efficient synthesis of 2-(trifluoromethyl)nicotinic acid derivatives from simple fluorinated precursors

Org Lett. 2008 May 1;10(9):1835-7. doi: 10.1021/ol800458k. Epub 2008 Apr 10.


Novel routes to 2-trifluoromethyl-nicotinic acid derivatives have been developed involving synthesis of the pyridine ring. These pyridyl compounds serve as key intermediates in the manufacture of the recently discovered COMT inhibitor, 3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2-(trifluoromethyl)pyridine 1-oxide.

MeSH terms

  • Nicotinic Acids / chemical synthesis*
  • Nicotinic Acids / chemistry
  • Nitriles / chemistry


  • Nicotinic Acids
  • Nitriles