Aging of the immune system as a prognostic factor for human longevity

Physiology (Bethesda). 2008 Apr;23:64-74. doi: 10.1152/physiol.00040.2007.


Accumulating data are documenting an inverse relationship between immune status, response to vaccination, health, and longevity, suggesting that the immune system becomes less effective with advancing age and that this is clinically relevant. The mechanisms and consequences of age-associated immune alterations, designated immunosenescence, are briefly reviewed here.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / immunology*
  • Humans
  • Immune System / physiology*
  • Longevity / immunology*
  • Prognosis