The problem of peculiarity of hormonal adaptation in newborn babies with periventricular leucomalacia--a condition that causes lifelong disability, in spite of its scientific and practical value is not adequately explored. The aim of the research was to investigate hormonal characteristics in the newborn babies with periventricular leucomalacia and to determine clinical and laboratory criteria for early prognosis of periventricular leucomalacia. Dynamic observation was conducted on 48 newborn babies who had acute and traumatic periventricular leucomalacia. Concentration of thyrotrophic hormone (TTH), tiroxine (T4) and triodtironin (T3) were determined in venous blood of the newborn babies on their first and fifth days of life. Cortisol was determined by the radioimmune method (RIA). The investigation revealed definite normal-adaptational reactions. Changes of hormonal traumatic periventricular leucomalacia, manifested in reduction of TTG, T3 level; concentration of T4 was moderately high.