C-Peptide and atherogenesis: C-Peptide as a mediator of lesion development in patients with type 2 diabetes mellitus?

Exp Diabetes Res. 2008:2008:385108. doi: 10.1155/2008/385108.


Patients with insulin resistance and early type 2 diabetes exhibit an increased propensity to develop a diffuse and extensive pattern of arteriosclerosis. Typically, these patients show increased levels of C-peptide and over the last years various groups examined the effect of C-peptide in vascular cells as well as its potential role in lesion development. While some studies demonstrated beneficial effects of C-peptide, for example, by showing an inhibition of smooth muscle cell proliferation, others suggested proatherogenic mechanisms in patients with type 2 diabetes. Among them, C-peptide may facilitate the recruitment of inflammatory cells into early lesions and promote lesion progression by inducing smooth muscle cell proliferation. The following review will summarize the effects of C-peptide in vascular cells and discuss the potential role of C-peptide in atherogenesis in patients with type 2 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Atherosclerosis / blood*
  • C-Peptide / blood*
  • Cell Division
  • Chemotaxis, Leukocyte
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetic Angiopathies / blood*
  • Humans
  • Muscle, Smooth, Vascular / pathology
  • Muscle, Smooth, Vascular / physiopathology


  • C-Peptide