Central skeletal sarcoidosis mimicking metastatic disease

Skeletal Radiol. 2008 Aug;37(8):757-61. doi: 10.1007/s00256-008-0479-7. Epub 2008 Apr 10.


Sarcoidosis is a systemic disease that histologically typically shows non-caseating granulomas. The most common radiologic finding is hilar and mediastinal adenopathy. Patients with widely disseminated disease may show involvement of the peripheral appendicular skeleton in 1-13% of such cases. A primary skeletal presentation without other manifestations typical of the disease is rare. We present a case of sarcoidosis in a middle-aged Caucasian man in whom the disease presented with widespread lytic lesions in the axial skeleton and long bones, mimicking metastatic disease. There was no involvement of the peripheral skeleton, skin or lungs.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Bone Diseases / diagnostic imaging*
  • Bone Neoplasms / diagnostic imaging
  • Diagnosis, Differential
  • Fluorodeoxyglucose F18
  • Humans
  • Male
  • Middle Aged
  • Radiopharmaceuticals
  • Sarcoidosis / diagnostic imaging*
  • Tomography, Emission-Computed
  • Tomography, X-Ray Computed


  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18