Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis

J Neuroimmunol. 2008 Mar;195(1-2):140-5. doi: 10.1016/j.jneuroim.2008.01.002. Epub 2008 Apr 10.


Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). In MS, myeloid dendritic cells (mDCs) secrete elevated amounts of IL-23, a potent proinflammatory cytokine, compared to healthy donors. Here, we examined the role of CD46, a complement binding factor, in mDCs by analyzing cytokine and chemokine production in healthy donors and patients with MS. There were striking differences between these groups with increased IL-23p19, CCL3 and CCL5 production, but decreased CCL2 levels in patients. This demonstrates major differences of DC activation upon CD46 activation, with a potential role in the pathogenesis of MS.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chemokines / metabolism*
  • Dendritic Cells / drug effects
  • Dendritic Cells / metabolism*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Interleukin-23 / metabolism*
  • Lipopolysaccharides / pharmacology
  • Lymphocyte Activation
  • Male
  • Membrane Cofactor Protein / genetics
  • Membrane Cofactor Protein / metabolism*
  • Middle Aged
  • Multiple Sclerosis / drug therapy
  • Multiple Sclerosis / pathology*
  • Statistics, Nonparametric


  • Chemokines
  • Interleukin-23
  • Lipopolysaccharides
  • Membrane Cofactor Protein