Promoting of wakefulness by administrations of modafinil into anterior hypothalamus and into the pedunculopontine tegmental nucleus in rats

Neurosci Lett. 2008 May 9;436(2):283-7. doi: 10.1016/j.neulet.2008.03.048. Epub 2008 Mar 22.

Abstract

We investigated whether administration of MOD in rats during the lights-on period into wake-promoting areas, such as anterior hypothalamus (AH) or into the pedunculopontine tegmental nucleus (PPTg) would enhance waking. Results showed that microinjections of 1 microL of MOD (10, 20, or 30 microg) into both brain areas increased the total time of alertness and decreased sleep. Additionally, MOD-treated rats showed an enhancement in alpha power spectra but delta power spectra was diminished. Finally, c-Fos expression was found increased into either AH or the PPTg. Collectively, these results suggest that MOD induces waking via the activity of two wake-related brain areas such as AH and the PPTg.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Anterior Hypothalamic Nucleus / drug effects*
  • Behavior, Animal / drug effects
  • Benzhydryl Compounds / pharmacology*
  • Central Nervous System Stimulants / pharmacology*
  • Dose-Response Relationship, Drug
  • Electroencephalography / methods
  • Male
  • Modafinil
  • Oncogene Proteins v-fos / metabolism
  • Pedunculopontine Tegmental Nucleus / drug effects*
  • Rats
  • Rats, Wistar
  • Sleep Stages / drug effects
  • Wakefulness / drug effects*

Substances

  • Benzhydryl Compounds
  • Central Nervous System Stimulants
  • Oncogene Proteins v-fos
  • Modafinil