Domiciliary oxygen therapy improves sub-maximal exercise capacity and quality of life in chronic heart failure

Heart Lung Circ. 2008 Jun;17(3):220-3. doi: 10.1016/j.hlc.2007.10.008. Epub 2008 Apr 9.


Introduction: A high prevalence of nocturnal hypoxia is noted in patients with chronic heart failure (CHF). Nocturnal hypoxia can be reversed by nasal oxygen or non-invasive assisted ventilation. However, controversy exists over the use of oxygen in CHF. We studied the effects of nocturnal nasal oxygen in CHF to demonstrate its effects on 6-min walk test, quality of life (QOL), NTproBNP, and echocardiographic parameters.

Methodology: Ten patients aged 70+/-9 years received domiciliary oxygen (4 l/min) for one month. Oxygen was administered for a minimum of 8h every night via nasal prongs.

Results: A 17% improvement was seen in the 6-min walk test, 298+/-98 m to 351+/-100 m (p=0.005) and a 27% improvement in the QOL, which improved from 26+/-12 to 19+/-7 (p=0.017). Acquired echocardiographic measures including ejection fraction, pulmonary pressure and diastolic parameters did not change.

Conclusion: Nocturnal nasal oxygen has a significant impact on sub-maximal exercise capacity and QOL in CHF. Although a previous study has demonstrated harmful haemodynamic effects of acute oxygen administration in CHF; we did not detect any change in echocardiographic parameters using current two-dimensional imaging and Doppler studies. The lack of improvement in cardiac parameters suggests a peripheral mode of action.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Exercise Test
  • Exercise Tolerance*
  • Female
  • Heart Failure / physiopathology
  • Heart Failure / therapy*
  • Humans
  • Hypoxia / therapy
  • Male
  • Middle Aged
  • Oxygen Inhalation Therapy / methods*
  • Quality of Life
  • Self Administration
  • Stroke Volume / physiology