Death through a tragedy: mitotic catastrophe

Cell Death Differ. 2008 Jul;15(7):1153-62. doi: 10.1038/cdd.2008.47. Epub 2008 Apr 11.


Mitotic catastrophe (MC) has long been considered as a mode of cell death that results from premature or inappropriate entry of cells into mitosis and can be caused by chemical or physical stresses. Whereas it initially was depicted as the main form of cell death induced by ionizing radiation, it is today known to be triggered also by treatment with agents influencing the stability of microtubule, various anticancer drugs and mitotic failure caused by defective cell cycle checkpoints. Although various descriptions explaining MC exist, there is still no general accepted definition of this phenomenon. Here, we present evidences indicating that death-associated MC is not a separate mode of cell death, rather a process ('prestage') preceding cell death, which can occur through necrosis or apoptosis. The final outcome of MC depends on the molecular profile of the cell.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Cell Biology / history*
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism*
  • Cell Death* / genetics
  • DNA Damage
  • Giant Cells / metabolism
  • Giant Cells / pathology
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Microtubule Proteins / genetics
  • Microtubule Proteins / metabolism*
  • Mitosis* / genetics
  • Necrosis
  • Terminology as Topic


  • Cell Cycle Proteins
  • Microtubule Proteins