Insulin resistance, premature adrenarche, and a risk of the Polycystic Ovary Syndrome (PCOS)

Trends Endocrinol Metab. 1998 Feb;9(2):72-7. doi: 10.1016/s1043-2760(98)00014-9.


Timing of puberty and final height are usually normal in girls with a history of premature adrenarche. However, these patients show an increased frequency of ovarian hyperandrogenism, hyperinsulinism and dyslipemia at adolescence. The hyperinsulinemia and lipid disturbances can often be detected in the prepubertal period, recommending long-term follow-up of these patients into adulthood.