Microglial Fc receptors mediate physiological changes resulting from antibody cross-linking of myelin oligodendrocyte glycoprotein

J Neuroimmunol. 2008 May 30;196(1-2):35-40. doi: 10.1016/j.jneuroim.2008.02.002. Epub 2008 Apr 11.


Antibodies to myelin oligodendrocyte glycoprotein (MOG) have been implicated in Multiple Sclerosis demyelination through activation of complement and/or macrophage-effector processes. We presented a novel mechanism, whereby MOG on oligodendrocytes, when cross-linked with anti-MOG and secondary antibody resulted in its repartitioning into lipid rafts, and changes in protein phosphorylation and morphology. Here, we show that similar events occur when anti-MOG is cross-linked with Fc receptors (FcRs) present on microglia but not with complement. These results indicate that FcRs are endogenous antigen/antibody cross-linkers in vitro, suggesting that FcRs could be physiologically relevant in vivo and possible targets for therapy in Multiple Sclerosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD / metabolism
  • Cell Death
  • Cells, Cultured
  • Cross-Linking Reagents / chemistry*
  • Cross-Linking Reagents / pharmacology
  • Immunoglobulin G / metabolism*
  • Immunoglobulin G / pharmacology
  • Myelin Basic Protein / metabolism
  • Myelin Proteins
  • Myelin-Associated Glycoprotein / immunology*
  • Myelin-Oligodendrocyte Glycoprotein
  • Oligodendroglia / drug effects
  • Oligodendroglia / metabolism*
  • Rats
  • Receptors, Fc / physiology*
  • Time Factors
  • beta-Cyclodextrins / pharmacology


  • Antigens, CD
  • Cross-Linking Reagents
  • Immunoglobulin G
  • Mog protein, rat
  • Myelin Basic Protein
  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • Myelin-Oligodendrocyte Glycoprotein
  • Receptors, Fc
  • beta-Cyclodextrins
  • methyl-beta-cyclodextrin