Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Aug 28;267(2):197-203.
doi: 10.1016/j.canlet.2008.03.004. Epub 2008 Apr 11.

Pro-inflammatory Prostaglandins and Progression of Colorectal Cancer

Affiliations
Free PMC article
Review

Pro-inflammatory Prostaglandins and Progression of Colorectal Cancer

Dingzhi Wang et al. Cancer Lett. .
Free PMC article

Abstract

Chronic inflammation is a risk factor for several gastrointestinal malignancies, including esophageal, gastric, hepatic, pancreatic and colorectal cancer. It has long been known that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduces the relative risk of developing colorectal cancer. NSAIDs exert their anti-inflammatory and anti-tumor effects primarily by inhibiting activity of cyclooxygenase (COX) enzymes. Cyclooxygenase enzymes catalyze the conversion of arachidonic acid into prostanoids, including prostaglandins (PGs) and thromboxanes (TXs). Emerging evidence demonstrates that prostaglandins play an important role in inflammation and cancer. In this review, we highlight recent breakthroughs in our understanding of the roles of the different prostaglandins in colorectal cancer (CRC) and inflammatory bowel disease (IBD). These findings may provide a rationale for the development of new anti-inflammatory therapeutic approaches to cancer prevention and/or treatment.

Similar articles

See all similar articles

Cited by 32 articles

See all "Cited by" articles

Publication types

Feedback