Mast cell transcriptional networks

Blood Cells Mol Dis. Jul-Aug 2008;41(1):82-90. doi: 10.1016/j.bcmd.2008.02.005. Epub 2008 Apr 14.

Abstract

Unregulated activation of mast cells can contribute to the pathogenesis of inflammatory and allergic diseases, including asthma, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. Absence of mast cells in animal models can lead to impairment in the innate immune response to parasites and bacterial infections. Aberrant clonal accumulation and proliferation of mast cells can result in a variety of diseases ranging from benign cutaneous mastocytosis to systemic mastocytosis or mast cell leukemia. Understanding mast cell differentiation provides important insights into mechanisms of lineage selection during hematopoiesis and can provide targets for new drug development to treat mast cell disorders. In this review, we discuss controversies related to development, sites of origin, and the transcriptional program of mast cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • GATA1 Transcription Factor / genetics
  • GATA1 Transcription Factor / metabolism
  • Gene Regulatory Networks*
  • Humans
  • Mast Cells / cytology
  • Mast Cells / immunology
  • Mast Cells / physiology*
  • Protein Isoforms / immunology
  • Protein Isoforms / metabolism
  • Transcription Factors / metabolism*

Substances

  • GATA1 Transcription Factor
  • Protein Isoforms
  • Transcription Factors