A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF

Science. 1991 Feb 22;251(4996):936-9. doi: 10.1126/science.1840698.


Macrophage-like U-937 cells secrete a 22-kilodalton heparin-binding growth factor that is mitogenic for BALB-3T3 fibroblasts and smooth muscle cells, but not endothelial cells. The amino acid sequence predicted from complementary DNA clones indicates that the mitogen is a new member of the epidermal growth factor (EGF) family. This heparin-binding EGF-like growth factor (HB-EGF) binds to EGF receptors on A-431 epidermoid carcinoma cells and smooth muscle cells, but is a far more potent mitogen for smooth muscle cells than is EGF. HB-EGF is also expressed in cultured human macrophages and may be involved in macrophage-mediated cellular proliferation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Cell Division / drug effects
  • Cell Line
  • Chromatography, Affinity
  • Chromatography, High Pressure Liquid
  • DNA Replication / drug effects
  • Epidermal Growth Factor / genetics
  • Epidermal Growth Factor / isolation & purification
  • Epidermal Growth Factor / metabolism*
  • Epidermal Growth Factor / pharmacology
  • ErbB Receptors / metabolism
  • Growth Substances / metabolism*
  • Heparin / metabolism*
  • Humans
  • Kinetics
  • Macrophages / metabolism*
  • Molecular Sequence Data
  • Protein Binding
  • Sequence Homology, Nucleic Acid


  • Growth Substances
  • Epidermal Growth Factor
  • Heparin
  • ErbB Receptors

Associated data

  • GENBANK/M60278
  • GENBANK/M61418
  • GENBANK/M61419
  • GENBANK/M61420
  • GENBANK/M61421
  • GENBANK/M61422
  • GENBANK/M61423
  • GENBANK/M61424
  • GENBANK/M61425
  • GENBANK/M61426