Antithrombotic therapy in peripheral arterial disease

Cardiol Clin. 2008 May;26(2):289-98, vii. doi: 10.1016/j.ccl.2007.12.004.

Abstract

The management of elderly patients with peripheral arterial disease requires a multidisciplinary and individualized approach, especially for patients requiring intervention and for those on antithrombotic therapy. Communication between the patient's primary physician, consulting medical specialists, and vascular surgeon is essential because all may contribute synergistically to deliver optimal care to the patient. This article reviews the pathophysiology of peripheral arterial disease and data regarding the use of antiplatelet and anticoagulant agents.

MeSH terms

  • Anticoagulants / administration & dosage
  • Aspirin / administration & dosage
  • Atherosclerosis / epidemiology
  • Cilostazol
  • Clopidogrel
  • Comorbidity
  • Diabetic Angiopathies / epidemiology
  • Humans
  • Hypertension / epidemiology
  • Intermittent Claudication / drug therapy
  • Intermittent Claudication / epidemiology
  • Pentoxifylline / administration & dosage
  • Peripheral Vascular Diseases / diagnosis
  • Peripheral Vascular Diseases / drug therapy*
  • Peripheral Vascular Diseases / epidemiology
  • Platelet Aggregation Inhibitors / administration & dosage
  • Platelet Aggregation Inhibitors / therapeutic use
  • Risk Factors
  • Smoking / epidemiology
  • Tetrazoles / administration & dosage
  • Thrombolytic Therapy*
  • Ticlopidine / administration & dosage
  • Ticlopidine / analogs & derivatives

Substances

  • Anticoagulants
  • Platelet Aggregation Inhibitors
  • Tetrazoles
  • Clopidogrel
  • Cilostazol
  • Ticlopidine
  • Aspirin
  • Pentoxifylline