Novel Pharmacological Strategies for Driving Inflammatory Cell Apoptosis and Enhancing the Resolution of Inflammation

Trends Pharmacol Sci. 2008 May;29(5):250-7. doi: 10.1016/j.tips.2008.03.002. Epub 2008 Apr 11.

Abstract

Resolution of inflammation requires the effective downregulation of key inflammatory cells such as neutrophils and eosinophils, which normally undergo programmed cell death (apoptosis) to enable their detection and removal by phagocytes such as macrophages. Dysregulation of this process is thought to contribute to the pathogenesis and progression of chronic inflammatory disorders such as chronic obstructive pulmonary disease, asthma, rheumatoid arthritis, allergic rhinitis and inflammatory bowel disease. Importantly, knowledge of the signalling pathways responsible for the induction and execution of granulocyte apoptosis and the phagocytic removal of apoptotic cells continues to increase and, with it, the potential for incisive pharmacological intervention. In this article, we highlight pharmacological strategies that could be used to drive the resolution of inflammation by augmenting apoptosis of inflammatory cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Apoptosis* / drug effects
  • Cyclin-Dependent Kinases / antagonists & inhibitors
  • Cyclin-Dependent Kinases / physiology
  • Granulocytes / immunology
  • Granulocytes / pathology
  • Humans
  • Inflammation / drug therapy
  • Inflammation / immunology
  • Inflammation / pathology*
  • MAP Kinase Signaling System / physiology
  • Phagocytosis / physiology
  • Phosphatidylinositol 3-Kinases / physiology
  • Proto-Oncogene Proteins c-bcl-2 / physiology
  • Signal Transduction / drug effects

Substances

  • Anti-Inflammatory Agents
  • Proto-Oncogene Proteins c-bcl-2
  • Phosphatidylinositol 3-Kinases
  • Cyclin-Dependent Kinases