Clinical evaluation of two bilateral hand allotransplantations at six and three years follow-up

Chir Main. 2008 Apr-Jun;27(2-3):109-17. doi: 10.1016/j.main.2008.02.002. Epub 2008 Mar 7.


We report a six and three years follow-up clinical evaluation of two bilateral hand allotransplantations from brain-dead multi-organs donors performed in two young adult traumatic hand amputees. Lifelong immunosuppressive treatment included tacrolimus, mycophenolate mofetil and prednisolone. In both patients, early complications were observed but were successfully treated. At follow-up, clinical results allow useful hand function in both patients, by far superior to what can be provided by current myoelectric prostheses. Although the long-term risks-benefits ratio of bilateral hand transplantation is still unknown, these two cases demonstrate that this new treatment is feasible. Further experimental and clinical research is needed to better delineate its role in the future of hand surgery.

Publication types

  • Case Reports
  • Evaluation Study

MeSH terms

  • Adult
  • Amputation, Traumatic / diagnostic imaging
  • Amputation, Traumatic / surgery*
  • Anti-Inflammatory Agents / therapeutic use
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Follow-Up Studies
  • Hand Injuries / diagnostic imaging
  • Hand Injuries / surgery*
  • Hand Transplantation*
  • Humans
  • Immunosuppression Therapy
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Mycophenolic Acid / analogs & derivatives
  • Mycophenolic Acid / therapeutic use
  • Prednisolone / therapeutic use
  • Radiography
  • Tacrolimus / therapeutic use
  • Time Factors
  • Tissue Donors
  • Transplantation, Homologous
  • Treatment Outcome


  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Immunosuppressive Agents
  • Prednisolone
  • Mycophenolic Acid
  • Tacrolimus