Prostate small cell carcinoma and skin metastases: a rare entity

Med Princ Pract. 2008;17(3):250-2. doi: 10.1159/000117801. Epub 2008 Apr 10.


Objectives: To report a rare case of small cell carcinoma of the prostate with unusual skin metastasis.

Clinical presentation and interventions: A 60-year-old was evaluated for difficulty in urinating. Abdominal computed tomography scans revealed a prostatic mass invading the surrounding tissues and multiple perirectal, periprostatic, para-aortic and pericaval lymph nodes. Needle biopsy specimens showed both small cell carcinoma and adenocarcinoma. He was treated with combination chemotherapy: cisplatin and etoposide and bilateral orchiectomy. After six cycles of the chemotherapy, disease progressed and the patient did not respond to salvage therapy; hence, palliative care was instituted. During the follow-up, papillary lesions were observed in the scrotal skin; biopsy showed metastatic small cell carcinoma.

Conclusion: Small cell carcinoma of the prostate is an aggressive disease with a highly metastatic potential; but skin metastases are very uncommon. It has poor prognosis despite therapy. Management resembles that of small cell carcinoma of the lung.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Biopsy, Needle
  • Carcinoma, Small Cell / drug therapy
  • Carcinoma, Small Cell / secondary*
  • Cisplatin / administration & dosage
  • Cyclophosphamide / administration & dosage
  • Doxorubicin / administration & dosage
  • Etoposide / administration & dosage
  • Fatal Outcome
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Prostatic Neoplasms / drug therapy
  • Prostatic Neoplasms / pathology*
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / drug therapy
  • Skin Neoplasms / secondary*
  • Vincristine / administration & dosage


  • Vincristine
  • Etoposide
  • Doxorubicin
  • Cyclophosphamide
  • Cisplatin