Curative embolization of cerebral arteriovenous malformations (AVMs) with Onyx in 101 patients

Neuroradiology. 2008 Jul;50(7):589-97. doi: 10.1007/s00234-008-0382-x. Epub 2008 Apr 12.


Introduction: Onyx has emerged in the recent years as a new embolic material. We present our experience with Onyx in the curative embolization of brain cerebral arteriovenous malformations (AVMs).

Methods: We retrospectively reviewed the files of all patients that we had treated with Onyx embolic material for a brain AVM during the last 4 years. We identified 101 patients who underwent a total of 219 sessions of embolization.

Results: The treatment has been concluded in 52 patients; in this group, total occlusion was obtained in 28 (53.9%) patients and near-total occlusion was obtained in 18 (34.6%). The respective figures based on the 101 patients of the study cohort are 28/101 (27.7%) and 18/101 (17.8%). More embolization sessions are to be carried out on the remaining 49 patients. There were three deaths, and eight patients had permanent neurological deficits with a resulting morbidity of 8% and mortality of 3%.

Conclusion: High rates of total or near-total occlusion of brain AVMs can be achieved with multiple sessions of Onyx embolization with acceptable morbidity and mortality.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Angioplasty*
  • Cohort Studies
  • Dimethyl Sulfoxide / therapeutic use*
  • Embolization, Therapeutic*
  • Female
  • Humans
  • Intracranial Aneurysm / complications
  • Intracranial Aneurysm / diagnostic imaging
  • Intracranial Aneurysm / therapy*
  • Intracranial Arteriovenous Malformations / complications
  • Intracranial Arteriovenous Malformations / diagnostic imaging*
  • Intracranial Arteriovenous Malformations / therapy*
  • Male
  • Middle Aged
  • Polyvinyls / therapeutic use*
  • Radiography
  • Retrospective Studies
  • Tantalum / therapeutic use
  • Treatment Outcome
  • Young Adult


  • Onyx copolymer
  • Polyvinyls
  • Tantalum
  • Dimethyl Sulfoxide