Paraganglioma in pituitary fossa

Neuropathology. 2008 Oct;28(5):547-50. doi: 10.1111/j.1440-1789.2008.00885.x. Epub 2008 Apr 11.


Paragangliomas are neuroendocrine tumors of paraganglionic tissue which are extremely rare in the sellar area. We present a case of sellar paraganglioma with parasellar and suprasellar extension in a 70-year-old man who presented with headache. CT demonstrated sellar mass with suprasellar and right parasellar extension. The lesion was removed subtotally via a trans-sphenoidal approach. Histopathological diagnosis was paraganglioma. Differential diagnosis between paragangliomas and unusual types of pituitary adenomas, especially null-cell adenomas, is made by presence of cell nests (Zellballen) in paraganglioma, lack of immunopositivity for pituitary hormones, cytoplasmic immunopositivity for chromogranin A and neuron-specific enolase, and immunonegativity for cytokeratin 19, cytokeratin 20 and endomysial antibody. In the case of a mass in the sellar region, paraganglioma, although rare, should be included in the differential diagnosis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Diagnosis, Differential
  • Humans
  • Immunohistochemistry
  • Male
  • Paraganglioma, Extra-Adrenal / metabolism
  • Paraganglioma, Extra-Adrenal / pathology*
  • Pituitary Neoplasms / metabolism
  • Pituitary Neoplasms / pathology*
  • Tomography, X-Ray Computed