Regression of herpes viral infection symptoms using melatonin and SB-73: comparison with Acyclovir

J Pineal Res. 2008 May;44(4):373-8. doi: 10.1111/j.1600-079X.2007.00538.x.

Abstract

Infection with Herpes simplex virus type 1 (HSV-1) typically causes lesions of the mouth, face, skin, esophagus, or brain. Herpes simplex virus type 2 (HSV-2) usually causes infections of the genitals, rectum, skin, hands, or meninges. The herpes viruses are a major cause of blindness from keratitis. The usual drugs used for herpes are Vidarabine, Acyclovir, Penciclovir and Ganciclovir; they are associated with several complications. The aim of this study was to investigate if a formulation containing 2.5 mg melatonin and 100 mg SB-73 would help patients with herpes, and to compare the preparation with 200 mg Acyclovir. SB-73 is a mixture of magnesium, phosphate, fatty acids extracted from Aspergillus sp. which has anti-herpes virus properties. A single blind randomized study was performed in which 70 patients underwent treatment using the supplement cited above (group A) and 75 received treatment of 200 mg Acyclovir (group B). Sixty-seven patients of the group A (95.7%) reported a complete regression of symptoms after 7 days of treatment. By comparison, 64 subjects (85.3%) of the Acyclovir reported regression of symptoms in the same period. There was statiscally significant difference between the groups (P < 0.05).

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyclovir / administration & dosage*
  • Adult
  • Antiviral Agents / administration & dosage*
  • Blindness / drug therapy
  • Blindness / etiology
  • Blindness / pathology
  • Blindness / virology
  • Central Nervous System Depressants / administration & dosage*
  • Female
  • Herpes Genitalis / complications
  • Herpes Genitalis / drug therapy*
  • Herpes Genitalis / pathology
  • Herpesvirus 1, Human*
  • Herpesvirus 2, Human*
  • Humans
  • Keratitis / drug therapy
  • Keratitis / etiology
  • Keratitis / pathology
  • Keratitis / virology
  • Linoleic Acids / administration & dosage*
  • Male
  • Melatonin / administration & dosage*
  • Organophosphorus Compounds / administration & dosage*
  • Single-Blind Method

Substances

  • Antiviral Agents
  • Central Nervous System Depressants
  • Linoleic Acids
  • Organophosphorus Compounds
  • magnesium ammonium phospholinoleate anhydride
  • Melatonin
  • Acyclovir