When ATPases pontin and reptin met telomerase

Dev Cell. 2008 Apr;14(4):459-61. doi: 10.1016/j.devcel.2008.03.018.

Abstract

Pontin and reptin are conserved AAA+ ATPases identified in chromatin-remodeling complexes. In a recent issue of Cell, Venteicher et al. provide new insight into the function of pontin and reptin in telomerase biogenesis, which is important for cellular senescence, aging, and cancer. These unexpected findings have implications for new avenues for development of effective therapeutic drugs in human disease.

MeSH terms

  • ATPases Associated with Diverse Cellular Activities
  • Animals
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • DNA Helicases / genetics
  • DNA Helicases / metabolism*
  • Humans
  • Multienzyme Complexes / metabolism
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Telomerase / genetics
  • Telomerase / metabolism*

Substances

  • Carrier Proteins
  • Cell Cycle Proteins
  • DKC1 protein, human
  • Multienzyme Complexes
  • Nuclear Proteins
  • TERT protein, human
  • Telomerase
  • ATPases Associated with Diverse Cellular Activities
  • DNA Helicases
  • RUVBL1 protein, human
  • RUVBL2 protein, human