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, 18 (9), 2924-9

Antagonists of the Human Adenosine A2A Receptor. Part 3: Design and Synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines

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Antagonists of the Human Adenosine A2A Receptor. Part 3: Design and Synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines

Roger J Gillespie et al. Bioorg Med Chem Lett.

Abstract

A series of pyrazolo[3,4-d]pyrimidine, pyrrolo[2,3-d]pyrimidine and 6-arylpurine adenosine A(2A) antagonists is described. Many examples were highly selective against the human A(1) receptor sub-type and were active in an in vivo model of Parkinson's disease.

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