Mutations of the human insulin receptor gene

S I Taylor; A Cama; H Kadowaki; T Kadowaki; D Accili

doi:10.1016/1043-2760(90)90024-w

Mutations of the human insulin receptor gene

Trends Endocrinol Metab. 1990 Jan-Feb;1(3):134-9. doi: 10.1016/1043-2760(90)90024-w.

Authors

S I Taylor¹, A Cama, H Kadowaki, T Kadowaki, D Accili

Affiliation

¹ Biochemistry and Molecular Pathophysiology Section, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

PMID: 18411106
DOI: 10.1016/1043-2760(90)90024-w

Abstract

Mutations in the insulin receptor gene have been identified in patients with genetic forms of insulin resistance. These mutations provide insight into structure-function relationships of the insulin receptor, and also into the causes of insulin resistance in human disease.