[Intracerebral progression of the transplanted rat C6 glioblastoma cells pretreated with neuropeptides and MAPK inhibitor]

Morfologiia. 2007;132(6):26-9.
[Article in Russian]


The authors have monitored C6 glioma cell invasive growth, proliferation and transcriptional regulation after pretreatment with endothelin-1 and ERK1/2 specific inhibitor PD98059. To explore proliferation of C6 glioma cells in different growth conditions, they were treated in vitro with endothelin-1 and implanted into the brain. In vitro studies have indicated that PD98059 inhibited the proliferation of cultured C6 glioma cells and induced the activation of E2F1 and Myc-Max transcriptional factors. Endothelin-1 strongly increased C6 glioma cell proliferation. The model used in this study is experimental, but it may provide an insight into the specific behavior of in vitro cultured invasive cells.

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism
  • Brain Neoplasms / metabolism
  • Brain Neoplasms / pathology*
  • Cell Line, Tumor
  • Cell Proliferation
  • E2F2 Transcription Factor / metabolism
  • Endothelin-1 / pharmacology
  • Endothelin-1 / physiology*
  • Extracellular Signal-Regulated MAP Kinases / antagonists & inhibitors
  • Extracellular Signal-Regulated MAP Kinases / metabolism*
  • Flavonoids / pharmacology
  • Glioblastoma / metabolism
  • Glioblastoma / pathology*
  • Male
  • Neoplasm Transplantation
  • Neuropeptides / pharmacology
  • Neuropeptides / physiology*
  • Proto-Oncogene Proteins c-myc / metabolism
  • Rats
  • Rats, Wistar


  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • E2F2 Transcription Factor
  • Endothelin-1
  • Flavonoids
  • Max protein, rat
  • Neuropeptides
  • Proto-Oncogene Proteins c-myc
  • Extracellular Signal-Regulated MAP Kinases
  • 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one