[Experience with using of solutions of hydroxyethyl starch (refortan and voluven) in neuroanesthesiology]

Vestn Khir Im I I Grek. 2007;166(6):56-60.
[Article in Russian]


The investigation has shown that solutions of hydroxyethyl starch included in complex infusion therapy facilitate stabilization of hemodynamics in neurosurgical patients during surgery. Refortan exerts a more pronounced effect on the indices of hemodynamics as compared with voluven, but its modifying action on the hemostasis system is also more pronounced. These medicines used in doses 6-8 ml/kg fail to have substantial effects on efficiency of hemostasis in the brain wound and do not increase risk of postoperative hemorrhagic complications.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Anesthesia / methods*
  • Hemodynamics / drug effects*
  • Homeostasis / drug effects*
  • Humans
  • Hydroxyethyl Starch Derivatives / administration & dosage*
  • Infusions, Intravenous
  • Intraoperative Care / methods
  • Middle Aged
  • Nervous System Diseases / physiopathology
  • Nervous System Diseases / surgery
  • Neurosurgical Procedures / methods*
  • Phenoxyacetates / administration & dosage*
  • Plasma Substitutes / administration & dosage*


  • HES 130-0.4
  • Hydroxyethyl Starch Derivatives
  • Phenoxyacetates
  • Plasma Substitutes
  • refortan