We report a case of Yersinia pseudotuberculosis (Y. pseudotuberculosis) septicemia in a healthy 22-year-old woman with clinical manifestations including high fever and general fatigue. The patient's ferer sudden elevation of her fever, and, liver damage and elevated inflammatory markers were indicated. General fatigue and appetite loss were noted on hospitalization. Exanthema was recognized, and all oral medications, including antibiotics, was stopped. The fever continued and high inflammatory parameters developed. After chemotherapy with imipenem, subjective symptoms ameliorated. Membranous desquamation without itching appeared between the fingers of both hands but improved naturally. Y. psuedotuberculosis septicemia was diagnosed as Y. psuedotuberculosis isolated from blood and elevated serum antibody titer against Y. psuedotuberculosis 4b detected at 1:160.