Nonrigid registration of multiple sclerosis brain images using lesion inpainting for morphometry or lesion mapping

Hum Brain Mapp. 2009 Apr;30(4):1060-7. doi: 10.1002/hbm.20566.


Morphometric studies of medical images often include a nonrigid registration step from a subject to a common reference. The presence of white matter multiple sclerosis lesions will distort and bias the output of the registration. In this article, we present a method to remove this bias by filling such lesions to make the brain look like a healthy brain before the registration. We finally propose a dedicated method to fill the lesions and present numerical results showing that our method outperforms current state of the art method.

Publication types

  • Research Support, Non-U.S. Gov't
  • Technical Report

MeSH terms

  • Algorithms
  • Brain / pathology*
  • Brain Mapping / methods*
  • Computer Simulation
  • Diagnostic Imaging*
  • Humans
  • Image Enhancement
  • Imaging, Three-Dimensional / methods
  • Multiple Sclerosis / diagnosis*
  • Registries*
  • Statistics, Nonparametric