Clinical resolution of glycogenic hepatopathy following improved glycemic control

J Diabetes Complications. Sep-Oct 2008;22(5):329-30. doi: 10.1016/j.jdiacomp.2007.11.004. Epub 2008 Apr 16.

Abstract

Glycogenic hepatopathy is an underrecognized complication of long-standing poorly controlled diabetes mellitus. It is characterized by abnormal glycogen accumulation in hepatocytes, elevated liver enzymes and hepatomegaly. This is a distinct entity from other causes of hepatomegaly and elevated liver enzymes in diabetics such as nonalcoholic fatty liver disease. It is important to distinguish this entity as it has the potential for resolution following improved glycemic control as described by this case report.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Blood Glucose / drug effects*
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / drug therapy*
  • Diabetes Mellitus, Type 1 / pathology
  • Female
  • Glycogen Storage Disease / drug therapy*
  • Glycogen Storage Disease / etiology
  • Glycogen Storage Disease / pathology
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Insulin / therapeutic use*
  • Liver Diseases / drug therapy*
  • Liver Diseases / etiology
  • Liver Diseases / pathology
  • Treatment Outcome

Substances

  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin