Carbon 11-labeled pittsburgh compound B positron emission tomographic amyloid imaging in patients with APP locus duplication

Arch Neurol. 2008 Apr;65(4):540-4. doi: 10.1001/archneur.65.4.540.


Objective: To investigate amyloid accumulation by carbon 11-labeled Pittsburgh Compound B (11C-PiB) in hereditary cerebral amyloid angiopathy and APP locus duplication.

Design, setting, and patients: Positron emission tomography with 11C-PiB and magnetic resonance imaging were performed for 2 patients, 49-year-old and 60-year-old siblings with APP locus duplication, with hereditary Alzheimer disease and cerebral amyloid angiopathy.

Main outcome measure: Change in 11C-PiB uptake.

Results: Uptake of 11C-PiB was increased especially in the striatum (caudate nucleus to 225% and 280% of the control mean and putamen to 166% and 185% of the control mean) and in the posterior cingulate (to 168% and 198% of the control mean), and it was marginally increased in other cortical brain areas. The pattern of increased 11C-PiB uptake was different from that seen in sporadic Alzheimer disease.

Conclusions: Amyloid imaging with 11C-PiB positron emission tomography is a useful tool for detecting in vivo amyloid accumulation in patients with hereditary cerebral amyloid angiopathy. However, the pattern of 11C-PiB accumulation differs between patients with typical AD and patients with APP locus duplication.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / diagnostic imaging*
  • Alzheimer Disease / genetics*
  • Amyloid beta-Protein Precursor / genetics*
  • Amyloid beta-Protein Precursor / metabolism
  • Aniline Compounds*
  • Brain / diagnostic imaging*
  • Carbon Radioisotopes*
  • Caudate Nucleus / diagnostic imaging
  • Cerebral Amyloid Angiopathy, Familial / diagnostic imaging*
  • Cerebral Amyloid Angiopathy, Familial / genetics
  • Dominance, Cerebral / physiology
  • Female
  • Gene Duplication
  • Gyrus Cinguli / diagnostic imaging
  • Hippocampus / diagnostic imaging
  • Humans
  • Image Processing, Computer-Assisted*
  • Magnetic Resonance Imaging*
  • Male
  • Mental Status Schedule
  • Middle Aged
  • Neuropsychological Tests
  • Parietal Lobe / diagnostic imaging
  • Positron-Emission Tomography*
  • Protease Nexins
  • Putamen / diagnostic imaging
  • Receptors, Cell Surface / genetics*
  • Receptors, Cell Surface / metabolism
  • Sensitivity and Specificity
  • Temporal Lobe / diagnostic imaging
  • Thiazoles*


  • 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
  • APP protein, human
  • Amyloid beta-Protein Precursor
  • Aniline Compounds
  • Carbon Radioisotopes
  • Protease Nexins
  • Receptors, Cell Surface
  • Thiazoles