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Comment
. 2008 Apr 22;105(16):5953-4.
doi: 10.1073/pnas.0802299105. Epub 2008 Apr 14.

Understanding epilepsy through network modeling

Astrid A Prinz  1
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Free PMC article
Comment

Understanding epilepsy through network modeling

Astrid A Prinz. Proc Natl Acad Sci U S A. .
Free PMC article
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Epileptic activity due to neuronal hubs. (A) Schematic of a network of granule cells (black circles) with random mossy fiber connections (arrows) sprouted after brain injury. (B) When a subset of neurons (located around granule cell number 25,000) is stimulated at time 0 ms, a model network with this synaptic connection topology does not exhibit seizure-like activity. Black dots in B represent granule cell action potentials. (C) Schematic of a granule cell network containing highly connected “hub” neurons (gray diamonds). (D) On stimulation of a subset of neurons at time 0 ms, a network with hub connectivity exhibits strong and long-lasting synchronous activity throughout the network—a seizure. Note that the simulations in B and D used the same total number of mossy fiber connections between granule cells. The epileptiform activity in D is therefore not due to a larger number of excitatory synaptic connections in the hub network.
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