Attenuated neuropathic pain in Cav3.1 null mice

Mol Cells. 2008 Apr 30;25(2):242-6. Epub 2008 Mar 28.


To assess the role of alpha(1G) T-type Ca2+ channels in neuropathic pain after L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking CaV3.1 (alpha1G(-/-)), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increased threshold for paw withdrawal in response to mechanical stimulation were observed in these mice. The alpha1G(-/-) mice also showed attenuated thermal hyperalgesia in response to both low-(IR30) and high-intensity (IR60) infrared stimulation. Our results reveal the importance of alpha(1G) T-type Ca2+ channels in the development of neuropathic pain, and suggest that selective modulation of alpha1G subtype channels may provide a novel approach to the treatment of allodynia and hyperalgesia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium Channels, T-Type / deficiency*
  • Calcium Channels, T-Type / metabolism
  • Infrared Rays
  • Mice
  • Mice, Inbred C57BL
  • Neuralgia / metabolism*
  • Pain Measurement
  • Reaction Time


  • Cacna1g protein, mouse
  • Calcium Channels, T-Type