Role for alkaline phosphatase as an inducer of vascular calcification in renal failure?

Kidney Int. 2008 May;73(9):989-91. doi: 10.1038/ki.2008.104.


Vascular calcification is associated with increased cardiovascular morbidity and mortality. A number of calcification inhibitors have been defined recently, including inorganic pyrophosphate (PP(i)), an important physicochemical inhibitor of hydroxyapatite crystal growth. Increased hydrolysis of PP(i) by tissue-nonspecific alkaline phosphatase (TNAP) may occur in renal failure and act to enhance mineralization of vessels.

Publication types

  • Comment

MeSH terms

  • Alkaline Phosphatase / physiology*
  • Animals
  • Calcinosis / enzymology*
  • Calcinosis / etiology*
  • Rats
  • Renal Insufficiency / complications*
  • Renal Insufficiency / enzymology*
  • Vascular Diseases / enzymology*
  • Vascular Diseases / etiology*


  • Alkaline Phosphatase