A primer on ankyrin repeat function in TRP channels and beyond

Mol Biosyst. 2008 May;4(5):372-9. doi: 10.1039/b801481g. Epub 2008 Mar 26.


Transient receptor potential (TRP) channels are rapidly gaining attention as important receptors and transducers of diverse sensory and environmental cues. Recent progress in the field has provided new insights into the structure and function of the ankyrin repeat motifs present in the N-terminal cytosolic domain of many TRP channels. The topics addressed in this Highlight include the structural features of canonical ankyrin repeats, new clues into the functions these repeats perform in cells, and how this information can be applied to develop further experiments on TRP channels and other proteins containing ankyrin repeats.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Ankyrin Repeat / physiology*
  • Ligands
  • Models, Molecular*
  • Protein Conformation
  • Transient Receptor Potential Channels / chemistry*
  • Transient Receptor Potential Channels / physiology*


  • Ligands
  • Transient Receptor Potential Channels