Signal transduction pathways used by NLR-type innate immune receptors

Mol Biosyst. 2008 May;4(5):380-6. doi: 10.1039/b718948f. Epub 2008 Mar 27.


Proteins from the nucleotide-binding domain, LRR containing (NLR) family are involved in sensing bacterial invasion and danger signals in mammalian cells. Activation of these molecules leads to inflammatory responses which help clearance of invading pathogens. Recent data now shed light on the signal transduction pathways used by NLR proteins. This review summarizes advances in our understanding of signalling through NLRs with special emphasis on the Nod1 and Nod2 pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Immunity, Innate*
  • Nod Signaling Adaptor Proteins / chemistry
  • Nod Signaling Adaptor Proteins / physiology*
  • Receptors, Cell Surface / chemistry
  • Receptors, Cell Surface / physiology*
  • Signal Transduction / immunology*


  • Nod Signaling Adaptor Proteins
  • Receptors, Cell Surface