[Pharmacology of disulfiram - an update]

Fortschr Neurol Psychiatr. 2008 Apr;76(4):225-31. doi: 10.1055/s-2007-1016438.
[Article in German]


Recently, we have been observing an increase in prescription of Disulfiram requiring medical knowledge concerning the overall effects, side effects and drug interactions of this substance. In the following report, we give an overview about the pharmacology and the side effects of Disulfiram. As an example we demonstrate a case, in which an acute neurological deficit was misjudged as a side effect of Disulfiram. Furthermore, the potential of Disulfiram as a promising treatment in addiction medicine will be discussed.

Publication types

  • Case Reports
  • English Abstract
  • Review

MeSH terms

  • Aged
  • Alcohol Deterrents / administration & dosage
  • Alcohol Deterrents / adverse effects
  • Alcohol Deterrents / pharmacology*
  • Alcohol Deterrents / therapeutic use*
  • Alcoholism / drug therapy*
  • Alcoholism / psychology
  • Antidepressive Agents / therapeutic use
  • Disulfiram / administration & dosage
  • Disulfiram / adverse effects
  • Disulfiram / pharmacology*
  • Disulfiram / therapeutic use*
  • Drug Interactions
  • Drug Therapy, Combination
  • Humans
  • Male


  • Alcohol Deterrents
  • Antidepressive Agents
  • Disulfiram