Novel markers of inflammation in atherosclerosis

Curr Atheroscler Rep. 2008 Apr;10(2):164-70. doi: 10.1007/s11883-008-0024-0.


Inflammation plays a key role in the pathogenesis of atherosclerosis. Understanding the process of inflammation as it pertains to atherosclerosis has provided researchers with multiple opportunities to identify novel markers for use in cardiovascular disease management. This article discusses the inflammatory cascade as it pertains to atherosclerosis and some of the well-studied markers of inflammation. It also discusses the limitations of current risk stratification models and characteristics of a good biomarker.

Publication types

  • Review

MeSH terms

  • 1-Alkyl-2-acetylglycerophosphocholine Esterase / physiology
  • Area Under Curve
  • Biomarkers / analysis*
  • C-Reactive Protein / analysis
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / physiopathology
  • Endothelium, Vascular / physiopathology
  • Humans
  • Inflammation / blood*
  • Inflammation / physiopathology
  • Peroxidase / blood
  • Peroxidase / physiology
  • ROC Curve
  • Risk Assessment


  • Biomarkers
  • C-Reactive Protein
  • Peroxidase
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase