Cardiac resynchronization: insight from experimental and computational models

Prog Biophys Mol Biol. 2008 Jun-Jul;97(2-3):543-61. doi: 10.1016/j.pbiomolbio.2008.02.024. Epub 2008 Mar 5.


Cardiac resynchronization therapy (CRT) is a promising therapy for heart failure patients with a conduction disturbance, such as left bundle branch block. The aim of CRT is to resynchronize contraction between and within ventricles. However, about 30% of patients do not respond to this therapy. Therefore, a better understanding is needed for the relation between electrical and mechanical activation. In this paper, we focus on to what extent animal experiments and mathematical models can help in order to understand the pathophysiology of asynchrony to further improve CRT.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Bundle-Branch Block / physiopathology*
  • Bundle-Branch Block / therapy
  • Cardiac Pacing, Artificial*
  • Feedback
  • Finite Element Analysis
  • Heart Conduction System*
  • Heart Failure / physiopathology
  • Heart Failure / prevention & control
  • Humans
  • Mechanotransduction, Cellular
  • Models, Cardiovascular*