Gene therapy progress and prospects cancer: oncolytic viruses

Gene Ther. 2008 Jun;15(12):877-84. doi: 10.1038/gt.2008.72. Epub 2008 Apr 17.


The past 2 years have seen several major advances in oncolytic virotherapy. Studies on the interaction between viruses, immune responses and tumor microenvironment have provided important insight, while clinical trials have shown promise. This review summarizes key findings in this field over the past 2 years, and provides directions for future success.

Publication types

  • Review

MeSH terms

  • Animals
  • Clinical Trials as Topic
  • Forecasting
  • Genetic Engineering
  • Genetic Therapy / methods*
  • Genetic Therapy / trends
  • Humans
  • Neoplasms / therapy*
  • Oncolytic Virotherapy / methods*
  • Oncolytic Virotherapy / trends
  • Oncolytic Viruses / genetics*