Infections in 252 patients with common variable immunodeficiency

Clin Infect Dis. 2008 May 15;46(10):1547-54. doi: 10.1086/587669.


Background: Common variable immunodeficiency is characterized by recurrent infections and defective immunoglobulin production.

Methods: The DEFI French national study prospectively enrolled adult patients with primary hypogammaglobulinemia. Clinical events before inclusion were retrospectively analyzed at that time.

Results: From April 2004 through April 2007, 341 patients were enrolled, 252 of whom had received a diagnosis of common variable immunodeficiency; of those, 110 were male, 142 were female, and 228 were white. The median age at first symptoms was 19 years. The median age at common variable immunodeficiency diagnosis was 33.9 years. The median delay for diagnosis was 15.6 years for the 138 patients with initial symptoms before 1990 and 2.9 years for the 114 patients with initial symptoms from 1990 to the time of the study. The most frequent initial symptoms were upper respiratory tract infections: bronchitis (in 38% of patients), sinusitis (36%), pneumonia (31%), and/or bronchiectasis (14%). Overall, 240 patients had respiratory symptoms. Pneumonia was reported in 147 patients; Streptococcus pneumoniae and Haemophilus influenzae were documented in 46 and 17 cases, respectively. Recurrent or chronic diarrhea was reported in 118 patients. Giardia (35 cases), Salmonella (19), and Campylobacter (19) infections were more frequent in patients with undetectable serum immunoglobulin A (P<.001). Sixteen patients developed opportunistic infections. Persistent infections and requirement for antibiotics despite immunoglobulin substitution correlated with severe defect of memory switched B cells (P=.003) but not with immunoglobulin G trough levels (P=.55).

Conclusion: Although reduced within the past decade, the delay of diagnosis of common variable immunodeficiency remains unacceptable. Recurrence of upper respiratory tract infection or pneumonia should lead to systematic evaluation of serum immunoglobulin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / therapeutic use
  • Child
  • Common Variable Immunodeficiency / complications*
  • Communicable Diseases / epidemiology
  • Communicable Diseases / etiology*
  • Diarrhea / epidemiology
  • Diarrhea / etiology
  • Female
  • Humans
  • Immunoglobulin G / blood
  • Male
  • Middle Aged
  • Pneumonia / epidemiology
  • Pneumonia / etiology
  • Prevalence
  • Respiratory Tract Infections / epidemiology
  • Respiratory Tract Infections / etiology
  • Time Factors


  • Anti-Bacterial Agents
  • Immunoglobulin G