Abstract
Cucurbitacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wv1 and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and antitumour activities of these norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12 micrograms/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Brazil
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Carcinoma 256, Walker / drug therapy*
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Cucurbitacins
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Drug Screening Assays, Antitumor
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Humans
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KB Cells / drug effects
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Phytotherapy*
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Plants, Medicinal / chemistry
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Rats
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Triterpenes / isolation & purification
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Triterpenes / therapeutic use*
Substances
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Antineoplastic Agents, Phytogenic
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Triterpenes
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Cucurbitacins