Synthesis and Characterization of Flavin Modified Oligodeoxyribonucleotide

Nucleic Acids Symp Ser. 1991;(25):69-70.

Abstract

Oligonucleotides covalently linked to isoalloxazines via polymethylene linker were synthesized and characterized. The thymidine decamer having a primary aminoalkyl group at the 5'-end of internucleotide linkage was coupled with the activated ester of isoalloxazine in liquid-phase. The interaction of the flavin modified thymidine decamers with polydA was investigated by using spectrophotometric method.

MeSH terms

  • Base Sequence
  • Flavins / chemistry*
  • Molecular Sequence Data
  • Molecular Structure
  • Oligodeoxyribonucleotides / chemical synthesis*
  • Oligodeoxyribonucleotides / chemistry

Substances

  • Flavins
  • Oligodeoxyribonucleotides