Levels of neurotransmitters in brain of vitamin B12 deficient rats

Int J Vitam Nutr Res. 1977;47(2):119-22.

Abstract

The levels of norepinephrine, dopamine and 5-hydroxytryptamine in brain homogenates of vitamin B12-deficient rats have been investigated. The norepinephrine levels were significantly decreased in the deficient animals compared to controls. The two major catabolic pathways of norepinephrine e.g. monoamine oxidase and catechol-O-methyl transferase did not show significant variations. Both acetyl cholinesterase and butiryl-cholinesterase markedly decreased in the plasma of the vitamin B12-deficient rats.

MeSH terms

  • Acetylcholinesterase / metabolism
  • Animals
  • Brain / enzymology
  • Brain / metabolism*
  • Catechol O-Methyltransferase / metabolism
  • Dopamine / metabolism
  • Female
  • Male
  • Monoamine Oxidase / metabolism
  • Neurotransmitter Agents / metabolism*
  • Norepinephrine / metabolism
  • Rats
  • Serotonin / metabolism
  • Vitamin B 12 Deficiency / metabolism*

Substances

  • Neurotransmitter Agents
  • Serotonin
  • Monoamine Oxidase
  • Catechol O-Methyltransferase
  • Acetylcholinesterase
  • Dopamine
  • Norepinephrine