Cytotoxic phenylpropanoids from carrot

J Agric Food Chem. 2008 May 14;56(9):3024-7. doi: 10.1021/jf7036517. Epub 2008 Apr 19.

Abstract

Carrot is widely used as a foodstuff. The active components such as beta-carotene and panaxynol have been studied by many researchers. In this investigation of nonpolar active components from carrot, a new phenylpropanoid, epilaserine oxide ( 3), was isolated along with six known compounds, laserine ( 1), 2-epilaserine ( 2), panaxynol ( 4), ginsenoyne K ( 5), (8 E)-1,8-heptadecadiene-4,6-diyne-3,10-diol ( 6), and vaginatin ( 7). Their structures were deduced on the basis of spectroscopic methods. Significant cytotoxicity of 2-epilaserine against HL-60 cells was observed, which implied that phenylpropanoids were cytotoxic compounds in carrot. Laserine and 2-epilaserine in carrots from diverse locations in China were quantified by HPLC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Benzodioxoles / analysis
  • Benzodioxoles / pharmacology
  • Butyrates / analysis
  • Butyrates / pharmacology
  • China
  • Chromatography, High Pressure Liquid
  • Daucus carota / chemistry*
  • HL-60 Cells
  • Humans
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology

Substances

  • Antineoplastic Agents, Phytogenic
  • Benzodioxoles
  • Butyrates
  • Plant Extracts
  • laserine