Efficacy and safety of cefovecin for the treatment of urinary tract infections in cats

J Small Anim Pract. 2008 Jun;49(6):295-301. doi: 10.1111/j.1748-5827.2008.00545.x. Epub 2008 Apr 14.


Objectives: To determine the efficacy and safety of cefovecin (Convenia); Pfizer Animal Health) in the treatment of urinary tract infections in cats.

Method: A multi-centre, masked, randomised study was conducted in cats presenting with clinical signs indicative of urinary tract infections. Cephalexin (Rilexine); Virbac) administered orally twice daily at 15 mg/kg bodyweight for 14 days was compared with a single subcutaneous injection of cefovecin in cats. The primary efficacy parameter assessed was bacterial elimination of the pretreatment uropathogen.

Results: Four hundred and thirty-four cats were screened for urinary tract infections. One hundred and eighty-five cats were treated with either cefovecin (n=124) or cephalexin (n=61). Ninety-seven cats (22.2 per cent) had confirmed bacteriuria and 82 cats were included in efficacy analysis. Escherichia coli was eliminated in 76.7 per cent (23 of 30) of cefovecin-treated cats compared with 62.5 per cent (10 of 16) of cephalexin-treated cats. Cefovecin demonstrated statistical non-inferiority compared with cephalexin for bacterial elimination. There were no suspected adverse drug reactions attributable to treatment with cefovecin or cephalexin.

Clinical significance: Cefovecin was demonstrated to be an effective and safe treatment for urinary tract infections.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Anti-Bacterial Agents / therapeutic use*
  • Cat Diseases / drug therapy*
  • Cats
  • Cephalosporins / therapeutic use*
  • Double-Blind Method
  • Escherichia coli Infections / drug therapy
  • Escherichia coli Infections / veterinary*
  • Female
  • Injections, Subcutaneous / veterinary
  • Male
  • Safety
  • Treatment Outcome
  • Urinary Tract Infections / drug therapy
  • Urinary Tract Infections / veterinary*


  • Anti-Bacterial Agents
  • Cephalosporins
  • cefovecin