miRiad roles for the miR-17-92 cluster in development and disease

Cell. 2008 Apr 18;133(2):217-22. doi: 10.1016/j.cell.2008.04.001.


MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. New work reveals essential functions for these miRNAs not only in tumor formation but also during normal development of the heart, lungs, and immune system.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Embryo, Mammalian / metabolism*
  • Heart / embryology
  • Humans
  • Immune System / embryology
  • Lung / embryology
  • Mice
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Multigene Family
  • Oncogenes
  • RNA, Neoplasm / genetics
  • RNA, Neoplasm / metabolism*


  • MIRN17 microRNA, human
  • MicroRNAs
  • RNA, Neoplasm