Regulation of cdc2 activity in Schizosaccharomyces pombe: the role of phosphorylation

Semin Cell Biol. 1991 Aug;2(4):195-204.


The cdc2 protein kinase, first identified as a cell cycle gene required for transition into the S- and M-phases of budding and fission yeast, has been shown to act as a key component in the regulation of the eukaryotic cell cycle. The periodic activation of cdc2 kinase, which is required for entry into M-phase, is regulated by subunit association with cyclin B, the cdc25, wee1, mik1 gene products and differential phosphorylation of the cdc2 protein. Phosphorylation at Tyr 15 inhibits activation of the cdc2/cdc13 complex whereas phosphorylation of Thr 167 is required for kinase activity.

Publication types

  • Review

MeSH terms

  • CDC2 Protein Kinase / genetics
  • CDC2 Protein Kinase / metabolism*
  • Cell Cycle / physiology
  • Enzyme Activation
  • Phenotype
  • Phosphorylation
  • Schizosaccharomyces / metabolism*


  • CDC2 Protein Kinase