Polymorphisms at the beta2-adrenergic receptor gene influence Alzheimer's disease susceptibility

Brain Res. 2008 May 19;1210:216-22. doi: 10.1016/j.brainres.2008.03.019. Epub 2008 Mar 20.

Abstract

Increasing evidence indicates that the beta2-adrenergic receptor (beta2-AR) may play an important role in Alzheimer's disease (AD). We investigated the effect of two polymorphisms in the beta2-AR gene: Gly16Arg and Gln27Glu for the risk of sporadic Late Onset Alzheimer's Disease (LOAD) in 109 patients and 109 healthy controls matched for sex and age in a Han Chinese population. Results revealed that both the 16Gly allele and the 27Glu allele of the beta2-AR gene were associated with an increased risk of LOAD (P=0.009, OR=1.652 and P=0.002, OR=2.846, respectively), and they also showed a highly significant interaction with the Apolipoprotein E gene (APOE) epsilon4 allele (OR=4.200 and 9.441, respectively). Examination of the haplotypes identified the Gly16Glu27 haplotype to increase the risk of LOAD (P=0.004). Our results suggest that variations in the beta2-AR gene play an important role in the pathogenesis of sporadic LOAD, and interact with the epsilon4 allele to markedly increase the LOAD risk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / ethnology
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism
  • Apolipoprotein E4 / genetics
  • Brain / metabolism
  • Brain / physiopathology
  • Brain Chemistry / genetics*
  • Catecholamines / metabolism
  • China / ethnology
  • DNA Mutational Analysis
  • Female
  • Gene Frequency
  • Genetic Markers / genetics
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing
  • Genotype
  • Haplotypes / genetics
  • Humans
  • Male
  • Mutation
  • Polymorphism, Genetic / genetics*
  • Receptors, Adrenergic, beta-2 / genetics*

Substances

  • Apolipoprotein E4
  • Catecholamines
  • Genetic Markers
  • Receptors, Adrenergic, beta-2