Genetic influences in common respiratory disorders

Crit Care Nurs Clin North Am. 2008 Jun;20(2):171-89, vi. doi: 10.1016/j.ccell.2008.01.009.


Respiratory disorders are common problems for adults and children in North America and generally represent the outcome of gene-environment interactions. Some problems are considered genetic in origin, such as cystic fibrosis, and others are considered environmental in origin, such as respiratory infections. Emerging information indicates that even genetic-based disorders are influenced by the environment and that environmental-based disorders are modified by personal genetic factors in individual physiologic responses. An understanding of an individual's personal risk factors for disease or health problem development can allow health care professionals to tailor health promotion strategies and treatment plans with appropriate environmental manipulation. This article explores the genetic influences that may affect the individual's physiologic responses and the consequences of environmental stimuli.

Publication types

  • Review

MeSH terms

  • Adult
  • Causality
  • Child
  • Critical Care
  • Cystic Fibrosis / etiology
  • Disease Susceptibility / etiology
  • Environmental Exposure / adverse effects
  • Environmental Illness / diagnosis
  • Environmental Illness / epidemiology
  • Environmental Illness / etiology
  • Environmental Illness / therapy
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics*
  • Genetic Predisposition to Disease / prevention & control
  • Genetic Testing
  • Genetic Variation / genetics
  • Humans
  • Immunity, Innate / genetics
  • Lung Neoplasms / etiology
  • Models, Biological
  • North America / epidemiology
  • Pulmonary Disease, Chronic Obstructive / etiology
  • Respiration Disorders / diagnosis
  • Respiration Disorders / epidemiology
  • Respiration Disorders / genetics*
  • Respiration Disorders / therapy
  • Respiratory Distress Syndrome / etiology
  • Smoking / adverse effects
  • Tuberculosis, Pulmonary / etiology