Rapid manifestation of CNS metastatic disease in a cervical carcinoma patient: a case report

Oncology. 2007;73(3-4):273-6. doi: 10.1159/000127426. Epub 2008 Apr 17.


Objectives: Brain metastases originating from primary cervical carcinoma are very rare. Despite surgery and adjuvant therapy, patient prognosis is extremely unfavorable. Prior studies have reported that the median time from the primary disease's diagnosis to development of CNS metastases is approximately 18 months.

Case report: A 60-year-old woman was initially diagnosed and treated for FIGO clinical stage IB2 cervical carcinoma in March 2007. She underwent a radical hysterectomy, bilateral salpingo-oophorectomy and peri-aortic lymphadenectomy. Two weeks later, the patient presented with dysmetria and homonymous hemianopsia, which was related to a large right occipital CNS metastasis. The patient had surgery to resect the brain tumor and then received Gamma Knife stereotactic radiosurgery and chemotherapy. The neurological deficits were resolved and the patient's disease status has since remained stable, with five months of follow-up.

Conclusion: The incidence of brain metastases originating from primary cervical carcinoma is very rare. Furthermore, the occurrence of CNS metastatic disease manifesting itself within a couple weeks following diagnosis of the primary disease is even more unusual. Since the presenting symptoms of CNS metastatic disease are not well characterized and patient prognosis is very poor, oncology physicians should anticipate the presence of this condition in order to provide prompt and comprehensive treatment.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Brain Neoplasms / secondary*
  • Brain Neoplasms / therapy
  • Carcinoma, Adenosquamous / secondary*
  • Carcinoma, Adenosquamous / surgery
  • Combined Modality Therapy
  • Female
  • Humans
  • Hysterectomy
  • Lymph Node Excision
  • Middle Aged
  • Ovariectomy
  • Radiosurgery
  • Uterine Cervical Neoplasms / pathology*
  • Uterine Cervical Neoplasms / surgery